Apomorphine‐induced penile erections in Parkinson's disease
Identifieur interne : 005069 ( Main/Exploration ); précédent : 005068; suivant : 005070Apomorphine‐induced penile erections in Parkinson's disease
Auteurs : John D. O'Sullivan [Australie] ; Andrew J. Hughes [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 1998-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Agonist, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Apomorphine, Apomorphine (administration & dosage), Apomorphine (adverse effects), Case study, Chemotherapy, Dopamine receptor, Erectile Dysfunction (drug therapy), Erection, Human, Humans, Injections, Subcutaneous, Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Penile Erection (drug effects), Penile erection, Sexual function, Subcutaneous administration, Toxicity.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Apomorphine.
- chemical , adverse effects : Antiparkinson Agents, Apomorphine.
- drug effects : Penile Erection.
- drug therapy : Erectile Dysfunction, Parkinson Disease.
- Adult, Aged, Humans, Injections, Subcutaneous, Male, Middle Aged.
Abstract
Penile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations. Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use. Animal studies suggest central D2‐type dopamine receptor stimulation and oxytocin release from the paraventricular nucleus of the hypothalamus mediate the effect. Erections reported with other dopamine agonists and levodopa are probably mediated by the same mechanism. Apomorphineinduced erections in PD are probably more common than previously thought. The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD.
Url:
DOI: 10.1002/mds.870130326
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998-05">1998-05</date><biblScope unit="vol">13</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="536">536</biblScope><biblScope unit="page" to="539">539</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">040754F5F6AD77F77096EBE03F8A3C5071983E97</idno><idno type="DOI">10.1002/mds.870130326</idno><idno type="ArticleID">MDS870130326</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Agonist</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Apomorphine</term><term>Apomorphine (administration & dosage)</term><term>Apomorphine (adverse effects)</term><term>Case study</term><term>Chemotherapy</term><term>Dopamine receptor</term><term>Erectile Dysfunction (drug therapy)</term><term>Erection</term><term>Human</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Penile Erection (drug effects)</term><term>Penile erection</term><term>Sexual function</term><term>Subcutaneous administration</term><term>Toxicity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Penile Erection</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Erectile Dysfunction</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Agoniste</term><term>Apomorphine</term><term>Chimiothérapie</term><term>Erection</term><term>Etude cas</term><term>Homme</term><term>Parkinson maladie</term><term>Récepteur dopaminergique</term><term>Toxicité</term><term>Voie souscutanée</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Penile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations. Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use. Animal studies suggest central D2‐type dopamine receptor stimulation and oxytocin release from the paraventricular nucleus of the hypothalamus mediate the effect. Erections reported with other dopamine agonists and levodopa are probably mediated by the same mechanism. Apomorphineinduced erections in PD are probably more common than previously thought. The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name></noRegion><name sortKey="Hughes, Andrew J" sort="Hughes, Andrew J" uniqKey="Hughes A" first="Andrew J." last="Hughes">Andrew J. Hughes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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